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Mealtime Dosing

Does meal size matter for BYETTA dosing?

No. The dose for BYETTA is the same, no matter how big or small your meal. You should not take BYETTA if you do not eat.

How far apart do BYETTA injections have to be given?

You should take your BYETTA doses within 60 minutes (1 hour) before your morning and evening meals (or before your two main meals of the day, at least 6 hours apart).

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What if I take BYETTA and don't eat, or I eat more than an hour after the injection?

You should eat within 60 minutes of injecting BYETTA. Taking BYETTA when a meal is missed should not result in hypoglycemia (low blood sugar). However, if you are taking a sulfonylurea or insulin with BYETTA, your risk of low blood sugar (glucose) will be higher.

What if I forget to take BYETTA and eat a meal?

If you forget to take a dose of BYETTA, skip that dose and wait until it is time for your next scheduled dose. DO NOT DOUBLE your next dose to "catch up" for missing a dose. Do not take BYETTA after eating a meal.

What should I be eating?

A healthy meal plan is one of the most important things you can do to help control your diabetes. Eating right doesn't mean you can't enjoy food anymore. It's more about knowing what's healthy and what's not, and finding foods you like that are good for you, too. Changing your diet to include healthier choices and preparing them more healthfully can make a big difference. A registered dietitian can help you develop a meal plan that works for you.

For more information about healthy eating, please visit the following websites:

How much should I eat at each meal?

How much you eat is just as important as what you eat. Since overeating is a major cause of obesity and other health problems, eating the right-sized portions is key to a healthier lifestyle.

Limit your serving sizes of meat to the size of the palm of your hand, or a deck of cards. Try to keep your servings of starchy vegetables and carbohydrates to the amount you could fit in your cupped hand. As a rule, if it looks like a lot of food to you, it probably is, so reduce your portions. Also, try eating more slowly. You will feel more full with less food. If you are dining out, don't feel you need to finish your plate. Stick with your plan to limit your portions, and remember, you can always take the rest home to eat another time.

When should I eat?

You should eat three meals a day at about the same time each day. If you eat a big dinner one day and a small dinner the next, your blood sugar levels will be harder to control. If you snack, you should also try to snack at the same time each day. Talk with your healthcare provider about how many meals and snacks to eat each day.

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Indication

BYETTA is an injectable prescription medicine that may improve blood sugar (glucose) control in adults with type 2 diabetes mellitus, when used with a diet and exercise program.

BYETTA is not insulin and should not be taken instead of insulin. BYETTA can be used with Lantus® (insulin glargine), which is a long-acting insulin, but should not be taken with short- and/or rapid-acting insulin. BYETTA is not for people with type 1 diabetes or people with diabetic ketoacidosis.

Important Safety Information for BYETTA® (exenatide) injection

  • Serious side effects can happen in people who take BYETTA, including inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Before taking BYETTA, tell your healthcare provider if you have had pancreatitis, stones in your gallbladder (gallstones), a history of alcoholism, or high blood triglyceride levels. Call your healthcare provider right away if you have pain in your stomach area (abdomen) that is severe, and will not go away. The pain may happen with or without vomiting and may be felt going from your abdomen through to your back.
  • Your risk for getting low blood sugar is higher if you take BYETTA with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. The dose of your sulfonylurea or insulin medicine may need to be lowered while you use BYETTA.
  • BYETTA should not be used in people who have severe kidney problems and should be used with caution in people who have had a kidney transplant. BYETTA may cause new or worse problems with kidney function, including kidney failure.
  • Before you use BYETTA, tell your healthcare provider if you have severe problems with your stomach, such as delayed emptying of your stomach (gastroparesis) or problems with digesting food.
  • Do not use BYETTA if you have had an allergic reaction to exenatide or any of the other ingredients in BYETTA. Severe allergic reactions can happen with BYETTA. Stop taking BYETTA and get medical help right away.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if BYETTA will harm your unborn baby. Talk to your healthcare provider first if you are breastfeeding or plan to breastfeed.
  • The most common side effects with BYETTA include nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, acid stomach, constipation, and weakness. Nausea most commonly happens when first starting BYETTA, but may become less over time.

These are not all the side effects with BYETTA. Talk to your healthcare provider about any side effect that bothers you or that does not go away.

Please see the BYETTA Prescribing Information and Medication Guide.