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BYETTA and Lantus (insulin glargine) Basics

If your doctor has prescribed BYETTA along with Lantus, please keep in mind:

  • BYETTA is approved for use with Lantus, but should not be taken with short- and/or rapid-acting insulin. BYETTA is not insulin and should not be taken instead of insulin.
  • When BYETTA is prescribed to be taken with Lantus, take BYETTA twice a day, within 60 minutes of your two main meals. Take your once-daily insulin as prescribed by your healthcare provider.
  • Consult with your doctor before you stop taking any medications. Your doctor will most likely add BYETTA to your treatment plan for type 2 diabetes while keeping you on any pills you are currently taking for diabetes in addition to Lantus. Of course, the decision is up to you and your doctor.
  • The most common side effect of taking BYETTA is mild to moderate nausea, which decreases over time for most people. The risk of getting low blood sugar is higher if you take BYETTA with another medicine that can cause low blood sugar, such as certain diabetes pills or insulin. In clinical studies, fewer than half the patients taking BYETTA and Lantus experienced nausea. Some common side effects that occurred more often in patients taking BYETTA with Lantus than in patients taking Lantus alone include nausea, vomiting, diarrhea, headache, constipation, and weakness.

Indication

BYETTA is an injectable prescription medicine that may improve blood sugar (glucose) control in adults with type 2 diabetes mellitus, when used with a diet and exercise program.

BYETTA is not insulin and should not be taken instead of insulin. BYETTA can be used with Lantus® (insulin glargine), which is a long-acting insulin, but should not be taken with short- and/or rapid-acting insulin. BYETTA is not for people with type 1 diabetes or people with diabetic ketoacidosis.

Important Safety Information for BYETTA® (exenatide) injection

  • Serious side effects can happen in people who take BYETTA, including inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Before taking BYETTA, tell your healthcare provider if you have had pancreatitis, stones in your gallbladder (gallstones), a history of alcoholism, or high blood triglyceride levels. Call your healthcare provider right away if you have pain in your stomach area (abdomen) that is severe, and will not go away. The pain may happen with or without vomiting and may be felt going from your abdomen through to your back.
  • Your risk for getting low blood sugar is higher if you take BYETTA with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. The dose of your sulfonylurea or insulin medicine may need to be lowered while you use BYETTA.
  • BYETTA should not be used in people who have severe kidney problems and should be used with caution in people who have had a kidney transplant. BYETTA may cause new or worse problems with kidney function, including kidney failure.
  • Before you use BYETTA, tell your healthcare provider if you have severe problems with your stomach, such as delayed emptying of your stomach (gastroparesis) or problems with digesting food.
  • Do not use BYETTA if you have had an allergic reaction to exenatide or any of the other ingredients in BYETTA. Severe allergic reactions can happen with BYETTA. Stop taking BYETTA and get medical help right away.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if BYETTA will harm your unborn baby. Talk to your healthcare provider first if you are breastfeeding or plan to breastfeed.
  • The most common side effects with BYETTA include nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, acid stomach, constipation, and weakness. Nausea most commonly happens when first starting BYETTA, but may become less over time.

These are not all the side effects with BYETTA. Talk to your healthcare provider about any side effect that bothers you or that does not go away.

Please see the BYETTA Prescribing Information and Medication Guide.

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02-05-1136-B ©2012 Amylin Pharmaceuticals, Inc.
The BYETTA mark, BYETTA design mark, BYETTA By Your Side mark, and BYETTA By Your Side design mark are registered trademarks of Amylin Pharmaceuticals, Inc.
All other trademarks are property of their respective owners.
This product, or its use, may be covered by one or more U.S. Patents including U.S. Patent Nos. 5,424,286, 6,858,576, 6,872,700, 6,902,744, 6,956,026, 7,297,761, 7,521,423, 7,741,269, in addition to others, including patents pending.
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