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Injecting BYETTA
Listed below are some of the most common questions people have about using the BYETTA Pen. For additional information and troubleshooting tips, please refer to the 5-mcg User Manual or 10-mcg User Manual. To view an interactive tutorial that demonstrates how to use the BYETTA Pen, click here.
BYETTA is a small protein called a peptide. Like all proteins, if BYETTA were to be taken by mouth, it would be digested, which would make it ineffective.
BYETTA should be injected under the skin of your upper leg (thigh), stomach area (abdomen), or upper arm as instructed by your healthcare provider.

Always wash your hands and clean the skin area where you are going to inject. Your healthcare provider may give you more specific information on how to prepare your injection site.
If the injections do not bother you, you do not have to change the general area of your injection site. If your skin gets irritated, you can choose a different injection site each time, using your upper leg, abdominal area, or upper arm.
Remove the needle by carefully putting the outer needle shield back over the needle. Unscrew and dispose of properly. Attach a new needle and repeat One-Time-Only New Pen Setup, Steps B–E, in Section 2 of the 5-mcg User Manual or 10-mcg User Manual. Once you see several drops or a stream of liquid coming out of the tip of the needle, the setup is complete.

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BYETTA is an injectable prescription medicine that may improve blood sugar (glucose) control in adults with type 2 diabetes mellitus, when used with a diet and exercise program.
BYETTA is not insulin and should not be taken instead of insulin. BYETTA is not recommended to be taken with insulin. BYETTA is not for people with type 1 diabetes or people with diabetic ketoacidosis.
Important Safety Information for BYETTA® (exenatide) injection
- Serious side effects can happen in people who take BYETTA, including inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Before taking BYETTA, tell your healthcare provider if you have had pancreatitis, stones in your gallbladder (gallstones), a history of alcoholism, or high blood triglyceride levels. Call your healthcare provider right away if you have pain in your stomach area (abdomen) that is severe, and will not go away. The pain may happen with or without vomiting and may be felt going from your abdomen through to your back.
- Your risk for getting low blood sugar is higher if you take BYETTA with another medicine that can cause low blood sugar, such as a sulfonylurea. The dose of your sulfonylurea medicine may need to be lowered while you use BYETTA.
- BYETTA should not be used in people who have severe kidney problems and should be used with caution in people who have had a kidney transplant. BYETTA may cause new or worse problems with kidney function, including kidney failure.
- Before you use BYETTA, tell your healthcare provider if you have severe problems with your stomach, such as delayed emptying of your stomach (gastroparesis) or problems with digesting food.
- Do not use BYETTA if you have had an allergic reaction to exenatide or any of the other ingredients in BYETTA. Severe allergic reactions can happen with BYETTA. Stop taking BYETTA and get medical help right away.
- Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if BYETTA will harm your unborn baby. Talk to your healthcare provider first if you are breastfeeding or plan to breastfeed.
- The most common side effects with BYETTA include nausea, vomiting, diarrhea, dizziness, headache, feeling jittery, and acid stomach. Nausea most commonly happens when first starting BYETTA, but may become less over time.
These are not all the side effects with BYETTA. Talk to your healthcare provider about any side effect that bothers you or that does not go away.
Please see the BYETTA Prescribing Information and Medication Guide.
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