Storage and Disposal Information

How should I store my BYETTA Pen?

• Prior to first use, store your new, unused BYETTA Pen in the original carton in a refrigerator at 36°F to 46°F (2°C to 8°C).
• After first use, your BYETTA Pen can be kept at a temperature not to exceed 77°F (25°C).
• Do not freeze your BYETTA Pen. Do not use BYETTA if it has been frozen. BYETTA should be protected from light.
• When carrying the pen away from home, store the pen at a temperature not to exceed 77°F (25°C) and keep dry.
• Do not store your BYETTA Pen with the needle attached. If the needle is left on, BYETTA may leak from the pen and air bubbles may form in the cartridge.
• Keep your pen and needles out of the reach of children.

How long can I use a BYETTA Pen?

• You can use your BYETTA Pen for up to 30 days after setting up a new pen for first use. After 30 days, throw away the BYETTA Pen, even if it is not completely empty.
• Mark the date when you first used your pen and the date 30 days later.
• BYETTA should not be used after the expiration date printed on the pen label.

How do I throw away my needles?

• Do not throw away the pen with a needle attached.
• Place used needles in a closeable, puncture-resistant container, such as a sharps container, a hard plastic detergent bottle, or a metal coffee can.
• Do not throw away the container in the household trash. Do not recycle. Keep out of reach of children.
• There may be state and local laws about how you should throw away used pens and needles. If you have questions, ask your healthcare provider for instructions.

Never share your BYETTA Pen with another person. You may give an infection to them, or get an infection from them, and BYETTA may harm them.

Be sure to read the User Manual that comes with your BYETTA Pen for more complete instructions.

Indication

BYETTA is an injectable prescription medicine that may improve blood sugar (glucose) control in adults with type 2 diabetes mellitus, when used with a diet and exercise program.

BYETTA is not insulin and should not be taken instead of insulin. BYETTA can be used with Lantus^® (insulin glargine), which is a long-acting insulin, but should not be taken with short- and/or rapid-acting insulin. BYETTA is not for people with type 1 diabetes or people with diabetic ketoacidosis.

Important Safety Information for BYETTA^® (exenatide) injection

• Serious side effects can happen in people who take BYETTA, including inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Before taking BYETTA, tell your healthcare provider if you have had pancreatitis, stones in your gallbladder (gallstones), a history of alcoholism, or high blood triglyceride levels. Call your healthcare provider right away if you have pain in your stomach area (abdomen) that is severe, and will not go away. The pain may happen with or without vomiting and may be felt going from your abdomen through to your back.
• Your risk for getting low blood sugar is higher if you take BYETTA with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. The dose of your sulfonylurea or insulin medicine may need to be lowered while you use BYETTA.
• BYETTA should not be used in people who have severe kidney problems and should be used with caution in people who have had a kidney transplant. BYETTA may cause new or worse problems with kidney function, including kidney failure.
• Before you use BYETTA, tell your healthcare provider if you have severe problems with your stomach, such as delayed emptying of your stomach (gastroparesis) or problems with digesting food.
• Do not use BYETTA if you have had an allergic reaction to exenatide or any of the other ingredients in BYETTA. Severe allergic reactions can happen with BYETTA. Stop taking BYETTA and get medical help right away.
• Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if BYETTA will harm your unborn baby. Talk to your healthcare provider first if you are breastfeeding or plan to breastfeed.
• The most common side effects with BYETTA include nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, acid stomach, constipation, and weakness. Nausea most commonly happens when first starting BYETTA, but may become less over time.

These are not all the side effects with BYETTA. Talk to your healthcare provider about any side effect that bothers you or that does not go away.

Please see the BYETTA Prescribing Information and Medication Guide.