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Who should not use BYETTA?

Do not use BYETTA if you have had an allergic reaction to exenatide or any of the other ingredients in BYETTA. See the end of the Medication Guide for a complete list of ingredients in BYETTA. Symptoms of a severe allergic reaction with BYETTA may include:

  • swelling of your face, lips, tongue, or throat
  • problems breathing or swallowing
  • severe rash or itching
  • fainting or feeling dizzy
  • very rapid heartbeat

If you have any symptoms of a severe allergic reaction, stop taking BYETTA and get medical help right away.

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Does BYETTA cause pancreatitis?

Inflammation of the pancreas (pancreatitis) may happen, which may be severe and lead to death. Before taking BYETTA, tell your healthcare provider if you have had pancreatitis, stones in your gallbladder (gallstones), a history of alcoholism, or high blood triglyceride levels. Stop taking BYETTA and call your healthcare provider right away if you have pain in your stomach area (abdomen) that is severe, and will not go away, occurs with or without vomiting or is felt going from your abdomen through to your back. These may be symptoms of pancreatitis.

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What do I need to know about hypoglycemia with BYETTA?

Your risk for getting low blood sugar (hypoglycemia) is higher if you take BYETTA with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. The dose of your sulfonylurea or insulin medicine may need to be lowered while you use BYETTA. Signs and symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery.

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If I have kidney problems, what do I need to know about BYETTA?

Tell your healthcare provider if you have or had kidney problems or a kidney transplant. BYETTA may cause new or worse problems with the way your kidneys work. Call your healthcare provider right away if you have nausea, vomiting, or diarrhea that will not go away, or if you cannot take liquids by mouth.

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What are the most common side effects seen with BYETTA?

The most common side effects with BYETTA include nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, acid stomach, constipation, and weakness. Nausea most commonly happens when first starting BYETTA, but may become less over time.

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Does BYETTA interact with any other medicines I take?

Before using BYETTA, tell your doctor about all the medicines you take, as taking them with BYETTA may affect how each medicine works. Tell your healthcare provider if you take other diabetes medicines, especially insulin or a sulfonylurea, or birth control pills, an antibiotic, warfarin sodium (Coumadin® or Jantoven®), a blood pressure medicine, water pill, pain medicine, or lovastatin (Altoprev®, Mevacor®, or Advicor®).

Your doctor may have prescribed BYETTA to be taken alone or along with other diabetes medicines. It can be used with metformin, a sulfonylurea, a thiazolidinedione, or insulin glargine (Lantus®), which is a long-acting insulin.

Ask your doctor or pharmacist to help you determine the best times to take your medications. If you forget to take your oral diabetes medications, you should talk with your doctor about the proper use of BYETTA.

BYETTA can slow down how quickly some medicines taken by mouth get into the bloodstream. For medications that need to be absorbed quickly, like birth control pills or antibiotics, you should take those medicines at least 60 minutes before injecting BYETTA. Make sure your doctor and pharmacist know all the medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

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What if I took or am taking BYETTA while pregnant?

Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if BYETTA will harm your unborn baby. Talk to your healthcare provider first if you are breastfeeding or plan to breastfeed.

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