Learn about BYETTA

Get answers to some frequently asked questions about the BYETTA Pen.

Do I need to do the One-Time-Only New Pen Setup before every dose?

No. The One-Time-Only New Pen Setup is done only once, just before each new pen is used for the first time. The purpose of the setup is to make sure that your BYETTA Pen is ready to use for the next 30 days.

If you repeat the One-Time-Only New Pen Setup before each routine dose, you will not have enough BYETTA (exenatide) injection for 30 days. The small amount of BYETTA used in the new pen setup will not affect the 30-day supply of BYETTA.

Why are there air bubbles in the cartridge?

A small air bubble is normal. It will not harm you or affect your dose.

If the pen is stored with a needle attached, air bubbles may form in the cartridge. Do not store the pen with the needle attached.

What should I do if BYETTA does not come out of the needle tip after 4 tries during the One-Time-Only New Pen Setup?

Carefully put the outer needle shield back over the needle. Remove the needle by unscrewing it. Throw away the needle properly.

Attach a new needle and repeat One-Time-Only New Pen Setup, Steps B–E, in Section 2 of the User Manual. Once you see several drops or a stream of liquid coming out of the tip of the needle, the setup is complete.

Why do I see BYETTA leaking from my needle after I have finished my injection?

It is normal for a single drop to remain on the tip of your needle after your injection is complete. If you see more than one drop:

  • You may not have received your full dose. Do not inject another dose. Talk with your healthcare provider about what to do about a partial dose.
  • To make sure that you get your full dose, when you take your injections, firmly push and hold the injection button in and slowly count to 5 (see Section 3, Step 4: Inject the Dose of the User Manual).

How can I tell when the injection is complete?

The injection is complete when:

  • You have firmly pushed the injection button in all the way until it stops
    and
  • You have slowly counted to 5 while you are still holding the injection button in and the needle is still in your skin
    and
  • The is in the center of the dose window.

If you hear a click sound from your BYETTA Pen, ignore it. You must follow all the steps listed above to make sure your injection is complete.

Where should I inject BYETTA?

Inject BYETTA into your abdomen, thigh, or upper arm using the injection method explained to you by your healthcare provider.

What if I cannot pull, turn, or push the dose knob?

Check the symbol in the dose window. Follow the steps next to the matching symbol.

If is in the dose window:

  • Pull the dose knob out until appears.

If is in the dose window and the dose knob will not turn:

  • The cartridge in your BYETTA Pen may not have enough medicine to deliver a full dose. A small amount of BYETTA will always stay in the cartridge. If the cartridge contains a small amount and the dose knob will not turn, your pen does not have enough BYETTA and will not deliver any more doses. Obtain a new BYETTA Pen.

If and part of are in the dose window and the dose knob cannot be pushed in:

  • The dose knob was not turned all the way. Continue turning the dose knob away from you until is in the center of the dose window.

If part of and part of are in the dose window and the dose knob cannot be pushed in:

  • The needle may be clogged, bent, or incorrectly attached.
  • Attach a new needle. Make sure needle is on straight and screwed on all the way.
  • Firmly push the injection button in all the way. BYETTA should come from needle tip.

If is in the dose window and the dose knob will not turn:

  • The injection button was not pushed in all the way and a complete dose was not delivered. Talk with your healthcare provider about what to do about a partial dose.
  • Follow these steps to reset your pen for your next injection:
    • Firmly push the injection button in all the way until it stops. Keep holding the injection button in and slowly count to 5. Then release the injection button and turn the dose knob away from you until appears in the dose window.
    • If you cannot turn the dose knob, the needle may be clogged. Replace the needle and repeat the step above.
  • For your next dose, be sure to firmly push and hold the injection button in and slowly count to 5 before removing needle from skin.

Please note: These FAQs apply to both the 5-mcg BYETTA Pen and the 10-mcg BYETTA Pen.

See the complete BYETTA Medication Guide that comes with BYETTA. For more information, call toll-free 1-800-868-1190.

IMPORTANT SAFETY INFORMATION for BYETTA® (exenatide) injection

  • Do not take BYETTA if you have had an allergic reaction to exenatide or any of the other ingredients in BYETTA. Severe allergic reactions can happen with BYETTA. Symptoms of a severe allergic reaction include severe rash or itching, swelling of your face, lips, and throat that may cause difficulty breathing or swallowing, feeling faint or dizzy and very rapid heartbeat. If you have any symptoms of a severe allergic reaction, stop taking BYETTA and get medical help right away.
  • Do not share your BYETTA Pen with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.
  • Inflammation of the pancreas (pancreatitis) may happen, which may be severe and lead to death. Before taking BYETTA, tell your healthcare provider if you have had pancreatitis, stones in your gallbladder (gallstones), a history of alcoholism, or high blood triglyceride levels. Stop taking BYETTA and call your healthcare provider right away if you have pain in your stomach area (abdomen) that is severe, and will not go away, occurs with or without vomiting or is felt going from your abdomen through to your back. These may be symptoms of pancreatitis.
  • Your risk for getting low blood sugar (hypoglycemia) is higher if you take BYETTA with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. The dose of your sulfonylurea or insulin medicine may need to be lowered while you use BYETTA. Signs and symptoms of low blood sugar may include headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery.
  • Tell your healthcare provider if you have or had kidney problems or a kidney transplant. BYETTA may cause new or worse problems with the way your kidneys work. Call your healthcare provider right away if you have nausea, vomiting, or diarrhea that will not go away, or if you cannot take liquids by mouth.
  • Tell your healthcare provider if you have severe problems with your stomach, such as delayed emptying of your stomach (gastroparesis) or problems with digesting food.
  • The most common side effects with BYETTA include nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, acid stomach, constipation, and weakness. Nausea most commonly happens when first starting BYETTA, but may become less over time.
  • Before using BYETTA, tell your doctor about all the medicines you take, as taking them with BYETTA may affect how each medicine works. Tell your healthcare provider if you take other diabetes medicines, especially insulin or a sulfonylurea, or birth control pills, an antibiotic, warfarin sodium (Coumadin® or Jantoven®), a blood pressure medicine, water pill, pain medicine, or lovastatin (Altoprev®, Mevacor®, or Advicor®). Take your birth control pills or antibiotics at least one hour before injecting BYETTA.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if BYETTA will harm your unborn baby. Talk to your healthcare provider first if you are breastfeeding or plan to breastfeed.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

WHAT IS BYETTA?

BYETTA is an injectable prescription medicine that may improve blood sugar (glucose) control in adults with type 2 diabetes, when used with diet and exercise. BYETTA is not insulin and should not be taken instead of insulin. BYETTA can be used with Lantus® (insulin glargine), which is a long-acting insulin, but should not be taken with short- and/or rapid-acting insulin.

BYETTA should not be used in people with type 1 diabetes or people with diabetic ketoacidosis (a condition caused by very high blood sugar). BYETTA is not recommended for use in children. BYETTA has not been studied in people who have pancreatitis. BYETTA should not be used in people who have severe kidney problems.

Please click here for Medication Guide and click here for US Full Prescribing Information for BYETTA (exenatide) injection.

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