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BYETTA Frequently Asked Questions (FAQs)

Get answers to some frequently asked questions about the 5-mcg and 10-mcg BYETTA Pen.

Do I need to do the One-Time-Only New Pen Setup before every dose?

No. The One-Time-Only New Pen Setup is done only once, just before each new pen is used for the first time. The purpose of the setup is to make sure that your BYETTA Pen is ready to use for the next 30 days.

If you repeat the One-Time-Only New Pen Setup before each routine dose, you will not have enough BYETTA injection for 30 days. The small amount of BYETTA used in the new pen setup will not affect the 30-day supply of BYETTA.

Why are there air bubbles in the cartridge?

A small air bubble is normal. It will not harm you or affect your dose.

If the pen is stored with a needle attached, air bubbles may form in the cartridge. Do not store the pen with the needle attached.

What should I do if BYETTA does not come out of the needle tip after 4 tries during the One-Time-Only New Pen Setup?

Carefully put the outer needle shield back over the needle. Remove the needle by unscrewing it. Throw away the needle properly.

Attach a new needle and repeat One-Time-Only New Pen Setup, Steps B–E, in Section 2 of the Instructions for Use. Once you see several drops or a stream of liquid coming out of the tip of the needle, the setup is complete.

Why do I see BYETTA leaking from my needle after I have finished my injection?

It is normal for a single drop to remain on the tip of your needle after your injection is complete. If you see more than one drop:

  • You may not have received your full dose. Do not inject another dose. Talk with your healthcare provider about what to do about a partial dose.
  • To make sure that you get your full dose, when you take your injections, firmly push and hold the injection button in and slowly count to 5 (see Section 3, Step 4: Inject the Dose of the Instructions for Use).

How can I tell when the injection is complete?

The injection is complete when:

  • You have firmly pushed the injection button in all the way until it stops
    and
  • You have slowly counted to 5 while you are still holding the injection button in and the needle is still in your skin
    and
  • The   is in the center of the dose window.

If you hear a click sound from your BYETTA Pen, ignore it. You must follow all the steps listed above to make sure your injection is complete.

Where should I inject BYETTA?

Inject BYETTA into your abdomen, thigh, or upper arm using the injection method explained to you by your doctor.

Examples of where to inject BYETTA

What if I cannot pull, turn, or push the dose knob?

Check the symbol in the dose window. Follow the steps next to the matching symbol.

If   is in the dose window:

  • Pull the dose knob out until   appears.

If   is in the dose window and the dose knob will not turn:

  • The cartridge in your BYETTA Pen may not have enough medicine to deliver a full dose. A small amount of BYETTA will always stay in the cartridge. If the cartridge contains a small amount and the dose knob will not turn, your pen does not have enough BYETTA and will not deliver any more doses. Obtain a new BYETTA Pen.

If   and part of   are in the dose window and the dose knob cannot be pushed in:

  • The dose knob was not turned all the way. Continue turning the dose knob away from you until   is in the center of the dose window.

If part of   and part of   are in the dose window and the dose knob cannot be pushed in:

  • The needle may be clogged, bent, or incorrectly attached.
  • Attach a new needle. Make sure the needle is on straight and screwed on all the way.
  • Firmly push the injection button in all the way. BYETTA should come from the needle tip.

If   is in the dose window and the dose knob will not turn:

  • The injection button was not pushed in all the way, and a complete dose was not delivered. Talk with your healthcare provider about what to do about a partial dose.
  • Follow these steps to reset your pen for your next injection:
    • Firmly push the injection button in all the way until it stops. Keep holding the injection button in and slowly count to 5. Then release the injection button and turn the dose knob away from you until   appears in the dose window.
    • If you cannot turn the dose knob, the needle may be clogged. Replace the needle and repeat the step above.
  • For your next dose, be sure to firmly push and hold the injection button in and slowly count to 5 before removing needle from skin.

See the complete Medication Guide and Instructions for Use that come with BYETTA. For more information, call toll-free 1-800-236-9933.

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BYETTA Pen Instructions for Use

 Click here to learn how to use the BYETTA Pen.