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What You Should Know About BYETTA

Now that you've started taking BYETTA injection to help improve your blood sugar control, it may be helpful to keep some important tips about your treatment in mind:



BYETTA + insulin glargine (Lantus®): Important Considerations

BYETTA and insulin glargine work in different ways to help you control your blood sugar. When you have type 2 diabetes, your blood sugar is especially high right after a meal—but it may also remain too high throughout the day. BYETTA helps lower your blood sugar, especially after meals. Insulin glargine provides a slow, steady release of insulin and helps manage your blood sugar between meals and overnight.

If your doctor has prescribed BYETTA along with insulin glargine, please keep the following in mind:

  • BYETTA is not insulin and should not be taken instead of insulin.
  • Take BYETTA twice a day, within 60 minutes of your 2 main meals approximately 6 hours or more apart. Take your once-daily insulin as prescribed by your doctor.
  • Do not mix BYETTA and insulin in the same syringe or vial even if you take them at the same time.
  • Consult with your doctor before you stop taking any medications. Your doctor will most likely add BYETTA to your treatment plan for type 2 diabetes while keeping you on any oral medications you are currently taking for diabetes, in addition to insulin glargine.

Keeping track of your progress

Periodic blood sugar monitoring is part of your diabetes plan while on BYETTA. Self-monitoring of blood sugar is important and will help you and your doctor determine how well your type 2 diabetes is controlled. Talk to your doctor for specific instructions on blood sugar testing. Based on your response to BYETTA, your doctor may increase the dose after a month.

Typically, your doctor will use a test called an A1C to determine how well your treatment is working. The A1C is a lab test that shows your average blood sugar level over the past 2-3 months. Because the A1C measures blood sugar over time, it is important that you follow your doctor’s instructions (including diet and exercise) and give your BYETTA treatment the full time until your next A1C.

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Taking BYETTA with other medicines

Your doctor has prescribed BYETTA in addition to your current diabetes medicines or diet and exercise program to help manage your blood sugar levels better.

Your doctor may have prescribed BYETTA to be taken alone or along with other diabetes medicines. It can be used with metformin, a sulfonylurea, a thiazolidinedione, or insulin glargine, which is a long-acting insulin.

Ask your doctor or pharmacist to help you determine the best times to take your medications. If you forget to take your oral diabetes medications, you should talk with your doctor about the proper use of BYETTA.

BYETTA can slow down how quickly some medicines taken by mouth get into the bloodstream. For medications that need to be absorbed quickly, like birth control pills or antibiotics, you should take those medicines 60 minutes before injecting BYETTA. Make sure your doctor and pharmacist know all the medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

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BYETTA Pen Instructions for Use

 Click here to learn how to use the BYETTA Pen.

Frequently Asked Questions

Get answers to some frequently asked questions about the BYETTA Pen.


See how non-insulin BYETTA compares to insulin lispro (mealtime insulin)


Important Safety Information

  • Before using BYETTA, tell your doctor about all the medicines you take, as taking them with BYETTA may affect how each medicine works. Tell your healthcare provider if you take other diabetes medicines, especially insulin or a sulfonylurea, or birth control pills, an antibiotic, warfarin sodium (Coumadin® or Jantoven®), a blood pressure medicine, water pill, pain medicine, or lovastatin (Altoprev®, Mevacor®, or Advicor®). Take your birth control pills or antibiotics at least one hour before injecting BYETTA.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if BYETTA will harm your unborn baby. Talk to your healthcare provider first if you are breastfeeding or plan to breastfeed.