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For many people, trying to maintain their blood sugar (glucose) levels day after day can be frustrating. BYETTA injection may be able to help. BYETTA is a non-insulin injection that may improve blood sugar control in adults with type 2 diabetes, when used with diet and exercise.

BYETTA + Insulin Glargine (Lantus®)

BYETTA + Oral Diabetes Medications

BYETTA + insulin glargine (Lantus®)

You may have been prescribed insulin glargine (a long-acting insulin) in addition to any oral diabetes medications you are already taking. To help improve your blood sugar control, your doctor may want to add BYETTA. BYETTA has been proven to help lower A1C when taken with insulin glargine.

In a 30-week clinical study, adults with type 2 diabetes using BYETTA with diet and exercise along with insulin glargine with or without oral antidiabetic medicines (metformin and/or thiazolidinedione) who added BYETTA*:

  • Lowered their A1C an average of 1.7% (starting from 8.3%) compared to an average reduction of 1.0% (starting from 8.5%) in those who did not add BYETTA.
  • Also, reduced weight by an average of 4 pounds (starting from 210 pounds) compared with patients who did not add BYETTA, who gained an average of 2.2 pounds (starting from 206 pounds).

Most common side effects seen with BYETTA used with insulin glargine in this 30-week study were: nausea, vomiting, diarrhea, headache, constipation, acid stomach, and weakness.

Additional side effects included: swelling (distention) of the abdomen, decreased appetite, gas (flatulence), and acid reflux.

Nausea usually decreases over time.

*BYETTA is not a weight loss drug. Individual results may vary.

BYETTA + oral diabetes medications

BYETTA may be taken with oral diabetes medications you may already be taking, such as metformin, sulfonylureas, and/or thiazolidinediones.

In 4 clinical studies ranging from 16 to 30 weeks, adults with type 2 diabetes taking BYETTA 10 mcg in addition to oral diabetes medications*:

  • Experienced A1C reductions ranging from 0.7% to 0.9% (starting at an A1C of 7.9%-8.6%)
  • Additionally, experienced weight reductions* ranging from 3.3 pounds to 5.7 pounds (starting at a weight of 209-222 pounds)

*BYETTA is not a weight-loss drug. Individual results may vary.

The most common side effects with BYETTA include nausea, vomiting, diarrhea, feeling jittery, dizziness, headache, acid stomach, constipation, and weakness. Nausea most commonly happens when first starting BYETTA, but may become less over time.

*Versus placebo.

Serious side effects can happen in people taking BYETTA, including inflammation of the pancreas (pancreatitis). Before taking BYETTA, tell your health care provider if you have had:

  • pancreatitis
  • stones in your gallbladder (gallstones)
  • a history of alcoholism
  • high blood triglyceride levels

These medical conditions can make you more likely to get pancreatitis in general. It is not known if having these conditions will lead to a higher chance of getting pancreatitis while taking BYETTA.

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Talk to Your Doctor About BYETTA

Get a discussion guide to help you discuss with your doctor if BYETTA is right for you.


See how non-insulin BYETTA compares to insulin lispro (mealtime insulin)


How BYETTA Works

Learn more about BYETTA, a GLP-1 receptor agonist.